Acute toxicity, antipyretic and antinociceptive study of the crude saponin from an edible vegetable:

dc.contributor.authorPaul Chukwuemeka, ADIUKWU
dc.contributor.authorAgaba, AMON
dc.contributor.authorGrace, NAMBATYA
dc.contributor.authorBulus, ADZU
dc.contributor.authorLawrence, IMANIRAMPA
dc.contributor.authorSilvano, TWINOMUJUNI
dc.contributor.authorOsbert, TWIKIRIZE
dc.contributor.authorMartin, AMANYA
dc.contributor.authorJoseph Obiezuchukwujekwu, EZEONWUMELU
dc.contributor.authorJoseph, OLORO
dc.contributor.authorGodwin Aiyabalu, OKORUWA
dc.contributor.authorBarbra, KATUSIIME
dc.date.accessioned2023-10-02T09:35:26Z
dc.date.available2023-10-02T09:35:26Z
dc.date.issued2012
dc.description.abstractVernonia amygdalina is commonly used for food and health purposes. Processing of the leaf for food is aimed at removing bitter tasting antinutritional principles like saponins. This study was designed to determine the antipyretic and antinociceptive property of the crude saponin from Vernonia amygdalina leaf. Standard procedure for antipyretic study using Saccharomyces cerevisiae induced pyrexia in rats; and acetic acid induced writhe, hot plate and cold tail flick tests for antinociceptive study in mice were used. Data for the crude saponin showed significant (P ≤ 0.05) dose dependent anal temperature decrease. The antinociceptive data in mice was significant (P ≤ 0.05) in the writhing test contrary to the cold tail flick test. In acute toxicity study, an LD50 of 5.1523 g/kg using oral route indicated it was practically non-toxic. Finding suggests that Vernonia amygdalina leaf prepared as diet could be of potential benefit to ailing persons with fever and/or pains, if processing technique adopts minimal loss of principles like saponinsen_US
dc.identifier.citationhttp://ajol.info/index.php/ijbcsen_US
dc.identifier.urihttps://ir.bsu.ac.ug//handle/20.500.12284/541
dc.language.isoen_USen_US
dc.publisherInternational Formulae Groupen_US
dc.subjectMiceen_US
dc.subjectoralen_US
dc.subjectpainen_US
dc.subjectpyrexiaen_US
dc.subjectraten_US
dc.titleAcute toxicity, antipyretic and antinociceptive study of the crude saponin from an edible vegetable:en_US
dc.title.alternativeVernonia amygdalina leafen_US
dc.typeWorking Paperen_US

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