The antiplasmodial and radical scavenging activities of flavonoids of Erythrina burttii.

dc.contributor.authorYenesew, Abiy
dc.contributor.authorAkala, Hoseah M.
dc.contributor.authorTwinomuhwezia, Hannington
dc.contributor.authorChepkirui, Carolyne
dc.contributor.authorBeatrice N
dc.contributor.authorIrungu
dc.contributor.authorEyaseb, Fredrick L
dc.contributor.authorKamatenesi-Mugisha, Maud
dc.contributor.authorBernard T.
dc.contributor.authorKiremire
dc.contributor.authorJacob D
dc.contributor.authorJohnson
dc.contributor.authorWaters, Norman C.
dc.date.accessioned2022-06-03T14:36:43Z
dc.date.available2022-06-03T14:36:43Z
dc.date.issued2012
dc.descriptionJournal articleen_US
dc.description.abstractThe acetone extract of the root bark of Erythrina burttii showed in vitro antiplasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 0.97±0.2 and 1.73±0.5 _g/ml respectively. The extract also had radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical with an EC50 value of 12.0 _g/ml. The isoflav-3-enes burttinol-A and burttinol-C, and the 2 arylbenzofuran derivative burttinol-D were identified as the most active antiplasmodial (IC50 < 10 _M) and free radical scavenging (EC50 ca. 10 _M) principles. The acetone extract of E. burttii at 800 mg/kg/day, in a 4-day Plasmodium berghei ANKA suppressive test, showed in vivo antimalarial activity with 52% chemosuppression. In the same in vivo test, marginal activities were also observed for the extracts of the root and stem bark of Erythrina abyssinica and the root bark of Erythrina sacleuxii.en_US
dc.identifier.urihttps://ir.bsu.ac.ug//handle/20.500.12284/306
dc.language.isoenen_US
dc.publisherElserveren_US
dc.subjectErythrina burttiien_US
dc.subjectRoot barken_US
dc.subjectLeguminosaeen_US
dc.subjectFlavonoiden_US
dc.subjectIsoflav-3-eneen_US
dc.subject2-Arylbenzofuranen_US
dc.subjectMalariaen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectPlasmodium bergheien_US
dc.subjectRadical scavengeren_US
dc.subjectDPPHen_US
dc.titleThe antiplasmodial and radical scavenging activities of flavonoids of Erythrina burttii.en_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
The_antiplasmodial_and_radical_scavenging_activiti kamatenesi mugisha prof..pdf
Size:
315.35 KB
Format:
Adobe Portable Document Format
Description:

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: