Origin and diversification of the human parasite Schistosoma mansoni

dc.contributor.authorKazibwe, Francis; Morgan, Jess A. T.; Dejong, Randall J.; Adeoye, Grace O.; Ansa, Ebenezer D. O.; Barbosa, Constança S.; Brémond, Philippe; Cesari, Italo M.; Charbonnel, Nathalie; Corrêa, Lygia R.; Coulibaly, Godefroy; D’andrea, Paulo Sérgio; De Souza, Cecilia Pereira; Doenhoff, Michael J.; File, Sharon; Idris, Mohamed A.; Incani, R. Nino; Jarne, Philippe; Karanja, Diana M. S.; Kpikpi, John; J. S, Nicholas; Mabaye, Amadou; Lwambo; Magalhães, Luiz A.; Makundi, Asanteli; Moné, Hélène; Mouahid, Gabriel; Muchemi, Gerald M.; Mungai, Ben N.; Séne, Mariama; Southgate, Vaughan; Tchuem Tchuenté, Louis Albert; Théron, Andre; Yousif, Fouad; Zanotti-Magalhães, Eliana M.; Mkoji, Gerald M.; Loker, Eric S.
dc.date.accessioned2022-06-13T07:52:03Z
dc.date.available2022-06-13T07:52:03Z
dc.date.issued2005
dc.descriptionHow S. mansoni genetic diversity is distributed geographically and among isolates using different hosts has never been examined with DNA sequence data.en_US
dc.description.abstractSchistosoma mansoni is the most widespread of the human-infecting schistosomes, present in 54 countries, predominantly in Africa, but also in Madagascar, the Arabian Peninsula, and the Neotropics. Adult-stage parasites that infect humans are also occasionally recovered from baboons, rodents, and other mammals. Larval stages of the parasite are dependent upon certain species of freshwater snails in the genus Biomphalaria, which largely determine the parasite’s geographical range. How Smansonigenetic diversity is distributed geographically and among isolates using different hosts has never been examined with DNA sequence data. Here we describe the global phylogeography of Smansoni using more than 2500 bp of mitochondrial DNA (mtDNA) from 143 parasites collected in 53 geographically widespread localities. Considerable within-species mtDNA diversity was found, with 85 unique haplotypes grouping into five distinct lineages. Geographical separation, and not host use,appears to be the most important factor in the diversification of the parasite. East African specimens showed a remarkable amount of variation, comprising three clades and basal members of a fourth, strongly suggesting an East African origin for the parasite 0.30–0.43 million years ago, a time frame that follows the arrival of its snail host. Less but still substantial variation was found in the rest of Africa. A recent colonization of the New World is supported by finding only seven closely related New World haplotypes which have West African affinities. All Brazilian isolates have nearly identical mtDNA haplotypes, suggesting a founder effect from the establishment and spread of the parasite in this large country.en_US
dc.description.sponsorshipThe Division of Vector-Borne Diseases, Ministry of Health, Kenyaen_US
dc.identifier.urihttps://ir.bsu.ac.ug//handle/20.500.12284/338
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.subjectAfricaen_US
dc.subjectBiomphalariaen_US
dc.subjectBrazilen_US
dc.subjectPhylogeographyen_US
dc.subjectSchistosomiasisen_US
dc.subjectSlave tradeen_US
dc.titleOrigin and diversification of the human parasite Schistosoma mansonien_US
dc.typeArticleen_US

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