Vernonia amygdalina is commonly used for food and health purposes. Processing of the leaf for food is
aimed at removing bitter tasting antinutritional principles like saponins. This study was designed to determine
the antipyretic and antinociceptive property of the crude saponin from Vernonia amygdalina leaf. Standard
procedure for antipyretic study using Saccharomyces cerevisiae induced pyrexia in rats; and acetic acid
induced writhe, hot plate and cold tail flick tests for antinociceptive study in mice were used. Data for the crude
saponin showed significant (P ≤ 0.05) dose dependent anal temperature decrease. The antinociceptive data in
mice was significant (P ≤ 0.05) in the writhing test contrary to the cold tail flick test. In acute toxicity study, an
LD50 of 5.1523 g/kg using oral route indicated it was practically non-toxic. Finding suggests that Vernonia
amygdalina leaf prepared as diet could be of potential benefit to ailing persons with fever and/or pains, if
processing technique adopts minimal loss of principles like saponins
